We are developing a pipeline of next-generation small-molecule GPCR-targeted treatments for endocrine and cardiometabolic diseases.
| Target | Modality | HIT ID | HIT to Lead | Lead Optimization | IND Enabling Studies | Early Clinical | Details |
|---|---|---|---|---|---|---|---|
| MC4R | Biased ligands | + |
The MC4R pathway plays a critical role in energy homeostasis and appetite regulation, with well-established clinical validation in rare genetic conditions such as Bardet-Biedl Syndrome (BBS) and hypothalamic obesity. Beyond these rare disorders, MC4R variants are also the most common genetic contributors to obesity in the general population. Superluminal’s molecule is designed to harness this biology in a highly selective manner, and to avoid side effects by activating only the relevant MC4R signaling pathways to offer a broad therapeutic window. In preclinical studies, the molecule demonstrated high MC1R selectivity and a favorable safety profile. |
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| GPCR 2 | Multi-functional ligands | + | |||||
| GPCR 3 | PAMs/NAMs | + | |||||
| GPCR 4 | Antagonists | + | |||||
| GPCR 5 | Biased ligands | + |
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